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卞劲松

卞劲松

卞劲松

首席研究员

phcbjs@nus.edu.sg
bianjs@sustech.edu.cn

教育背景

1985 — 1990 徐州医学院临床医学专业学士学位

1990 — 1993 南京医科大学基础医学院药理学专业,硕士学位
1997 — 2000 香港大学医学院生理学专业博士学位


工作经历

1993.7 — 1997.3 南京医科大学基础医学院药理学教研室,助理教授、讲师

2000.5 — 2003.9 美国心脏学会基金资助学者,美国爱因斯坦医学院博士后研究

2003.10 — 2008.12 新加坡国立大学医学院药理学助理教授

2009.1  — 2020.4 新加坡国立大学医学院药理学系副教授,终身教授
2020.5 — 至今 南方科技大学医学院药理学系教授


主要研究领域

1.硫化氢的生理药理学作用
2.钠钾ATP酶的新型生物学功能
3.  肺动脉高压的新靶点研究


荣誉、奖项

2017 新加坡国立大学医学院优秀科研成就奖(2015/2016年度)
2001 香港大学博士论文Dr. KP Stephen Chang 金牌
2001 美国心脏学会(American Heart Association)fellowship
2000 香港大学Mary Sun 学者奖
1999 香港大学Wong Ching Yee 优秀研究生奖
1999 香港—台湾第七届生理学年会Prof. A.C. Brown Prize奖
1998 香港大学优秀成绩荣誉证书
1997 中国南京医科大学十佳论文奖
1996 中国江苏省科技进步二等奖
1995 中国南京医科大学洛普奖教金


代表性论文

[1] Cao L, Xiong S, Wu Z, Ding L, Zhou Y, Sun H, Zhu M, Lee WT, Nie X*, Bian JS*. Anti-Na+/K+-ATPase immunotherapy ameliorates α-synuclein pathology through activation of Na+/K+-ATPase α1-dependent autophagy. Sci Adv. 2021 Jan 27;7(5):eabc5062. doi: 10.1126/sciadv.abc5062.
[2] Sun H, Xiong S, Cao X, Cao L, Zhu M, Wu Z*, Bian JS*. Polysulfide-mediated sulfhydration of SIRT1 prevents diabetic nephropathy by suppressing phosphorylation and acetylation of p65NF-κB and STST3. Redox Biology. 2021 Jan;38:101813. doi: 10.1016/j.redox.2020.101813.
[3] Nie X*, Shen C, Tan J, Wu Z, Wang W, Chen Y ,Dai Y, Yang X,  Ye S, Chen J, Bian JS*. Periostin: A Potential Therapeutic Target For Pulmonary Hypertension? Circ Res. 2020 Oct 9;127(9):1138-1152.
[4] Zhu M, Cao L, Xiong S, Sun H, Wu Z, Bian JS*. Na+/K+-ATPase-dependent autophagy protects brain against ischemic injury. Signal Transduction and Targeted Therapy. 2020 May 20;5(1):55. doi: 10.1038/s41392-020-0153-7.
[5] Cao X, Cao L, Zhang W, Lu R, Bian JS*, Nie X*. Therapeutic potential of sulfur-containing natural products in inflammatory diseases .Pharmacol Ther. 2020 Sep 20:107687. doi: 10.1016/j.pharmthera. 2020.107687.
[6] Sun HJ, Xiong SP, Wu ZY, Cao L, Zhu MY, Moore PK, Bian JS*. Induction of caveolin 3/eNOS complex by nitroxyl (HNO) ameliorates diabetic cardiomyopathy. Redox Biol. 2020 May;32:101493. doi: 10.1016/j.redox.2020.101493. 
[7] Sun HJ, Cao L, Zhu MY, Wu ZY, Shen CY, Nie XW, Bian JS*. DR-region of Na+/K+-ATPase is a target to ameliorate hepatic insulin resistance in obese diabetic mice .Theranostics. 2020 May 15;10(14):6149-6166. doi: 10.7150/thno.46053. eCollection 2020.

[8] Sun HJ, Wu ZY, Nie XW, Bian JS*. Implications of hydrogen sulfide in liver pathophysiology: mechanistic insights and therapeutic potential. Journal of Advanced Research, 2020.
[9] Sun HJ, Lee WT, Leng B, Wu ZY, Yang Y, Bian JS*. Nitroxyl as a Potential Theranostic in the Cancer Arena. Antioxid Redox Signal. 2020 Feb 10;32(5):331-349. doi: 10.1089/ars.2019.7904. 
[10] Sun HJ, Wu ZY, Cao L, Zhu MY, Nie XW, Huang DJ, Sun MT, Bian JS*.Role of nitroxyl (HNO) in cardiovascular system: From biochemistry to pharmacology. Pharmacol Res. 2020 May 29;159:104961. doi:10.1016/j.phrs.2020.104961
[11] Sun HJ, Wu ZY, Nie XW, Bian JS*. Role of Endothelial Dysfunction in Cardiovascular Diseases: The Link Between Inflammation and Hydrogen Sulfide. Front Pharmacol. 2020 Jan 21;10:1568.doi: .3389/fphar.2019.01568. eCollection 2019. 
[12] Cao X, Ding L, Xie ZZ, Yang Y, Whiteman M, Moore PK, Bian JS*. A Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: Is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer? Antioxid Redox Signal. 2019 Jul 1;31(1):1-38.
[13] Cao X, Zhang W, Moore PK, Bian J. Protective Smell of Hydrogen Sulfide and Polysulfide in Cisplatin-Induced Nephrotoxicity. Int J Mol Sci. 2019 Jan 14;20(2). pii: E313. doi: 10.3390/ijms20020313.
[14] Zhou YB, Zhou H, Li L, Kang Y, Cao X, Wu ZY, Ding L, Sethi G, Bian JS*. Hydrogen Sulfide Prevents Elastin Loss and Attenuates Calcification Induced by High Glucose in Smooth Muscle Cells through Suppression of Stat3/Cathepsin S Signaling Pathway. Int J Mol Sci. 2019 Aug 27;20(17). pii: E4202. doi: 10.3390/ijms20174202. 

[15]  Xie ZZ, Shi MM, Xie L, Wu ZY, Li G, Hua F, Bian JS*. Sulfhydration of p66Shc at cysteine59 mediates the anti-oxidant effect of Hydrogen Sulfide. Antioxid Redox Signal. 2014 Dec 20;21(18):2531-42.

[16] Yang HY, Wu ZY, Wood M, Whiteman M, Bian JS*. Hydrogen sulfide attenuates opioid dependence by suppression of adenylate cyclase/cAMP pathway. Antioxidants & Redox Signaling, 2014 Jan 1;20(1):31-41.

[17] Lu M, Zhao FF, Tang JJ, Su CJ, Fan Y, Ding JH, Bian JS*, Hu G*. The neuroprotection of hydrogen sulfide against MPTP-induced dopaminergic neuron degeneration involves UCP2 rather than K-ATP channels. Antioxidants & Redox Signaling, 2012, 15;17(6):849-59.
[18] Wu ZY, Yu DJ, Soong TW, Dawe GS, Bian JS*. Progesterone impairs HERG trafficking by disruption of intracellular cholesterol homeostasis. Journal of Biological Chemistry, 2011, 286(25):22186-94.

[19] Lu M, Liu YH, Goh HS, Wang JJX, Yong QC, Wang R, Bian JS*. Hydrogen sulfide inhibits plasma renin activity. J AM SOC NEPHROL, 201021(6):993-1002.


专利

[1] Therapeutic antibody,US provisional application number:62/873,207
[2] S-淫羊藿苷化合物,合成方法及用途. 卞劲松,蔡志明,吴海霞。专利号:20110258374.X
[3]S-紫丁香素化合物,合成方法及用途. 卞劲松,蔡志明,吴海霞。专利号:20110258261.X
[4]S-丹参素化合物,合成方法及用途。卞劲松,蔡志明,吴海霞。专利号:20110258761.3
[5] Identification of a Key Target on Na+/K+ ATPase To Prevent Osteoporosis. US Provisional Application No.: 61/786,874, ILO Ref: 13101N-US/PRV


专著

[1] Book title:Hydrogen sulfide: its production, release and functions
Chapter title: Hydrugen sulfide: physiological and pathological functions
Publisher:Springer
ISBN: 978-3-7091-1549-7
Editor/Authors: Hideo Kimura/YiTong Liu/ Jinsong Bian
[2] Book title:Methods in Enzymology. Hydrogen Sulfide in Redox Biology Part A & B
Chapter title:Neuroprotective effects of hydrogen sulfide in Parkinson’s disease animal models: Methods and Protocols
Publisher:ELSEVIER 
ISBN:  978-0-12-801512-4
ISSN: 0076-6879
Editor/Authors: Lester Packer and Enrique Cadenas/Xue Xue/Bian Jinsong
[3] Book title:Handbook of Experimental Pharmacology-Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide.
Chapter title:Brain, learning and memory: Role of H2S in neurodegenerative diseases
Publisher:Springer
ISBN: To be issued.
Editor/Authors: 
[4] Book title:Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide
Chapter title: Brain, Learning, and Memory: Role of H2S in Neurodegenerative Diseases
Publisher:Academic Press, Elsevier
ISBN: 978-3-319-18143-1
Editor/Authors: Philip K. Moore/Mat Whiteman/ Yang Haiyu/ Jinsong Bian
[5] Book title:The Neuropathology Of Drug Addictions And Substance Misuse.
Chapter title: Opioid Dependence and the Adenylyl yclase/cAMP Signaling
Publisher:Academic Press, Elsevier
ISBN: To be issued.
Editor/Authors: 
[6] Book title:Gasotransmitters: Metallobiolgoy
Chapter title: The interaction of NO and H2S signaling systems in biology and medicine
Publisher:The Royal Society of Chemistry
ISBN:To be issued.
Editor/Authors: Rui Wang/Cao Xu/ Jinsong Bian


学术兼职

国际硫化氢生物学会议科学顾问委员(历届)
欧洲硫化氢生物学会议科学顾问委员(历届)
亚洲血管生物学会委员(2005-现在)
亚洲血管生物学会专家委员会科学顾问委员(2005-现在)
新加坡国家医学研究基金评审终审委员会委员(2007-现在)
新加坡新药管理与评审中心评审专家(2006-现在)
希腊心血管疾病研究协会顾问委员 (2010-现在)
EPS 全球心脏国际会议顾问委员(重庆, April, 2011 )
日本药理科学杂志顾问编委(2011-现在,日本)
东吴论坛主席(2011,中国苏州)


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