黄德建_苏州工业园区新国大研究院

黄德建

首席研究员

fsthdj@nus.edu.sg

教育背景

1983—1987 福建师范大学化学系，理学学士
1987—1990 中国科学院兰州化学物理研究所，理学硕士
1994—1999 美国印第安纳大学，博士

工作经历

2022—至今新加坡国立大学，教授
2022—至今新加坡国立大学苏州研究院，首席研究员
2010—2021 新加坡国立大学，副教授
2020—2020 慕尼黑工业大学，客座教授
2014—2015 新加坡国立大学，代理主任
2013—2021 新加坡国立大学苏州研究院，高级研究员
2011—2011 北卡罗来纳大学教堂山分校，埃舍尔曼药学院，访问学者
2009—2010 新加坡国立大学，代理主任
2004—2009 新加坡国立大学，助理教授
2001—2004 Brunswick Laboratories，首席科学家
1999—2001 美国麻省理工学院，博士后
1990—1994 成都有机化学研究所，副研究员

研究领域

食用植物中的生物活性成分，中草药，膳食抗氧化剂和氧化应激调控，控制血糖的功能性食品
荧光分子和纳米探针，用于检测具有生物学重要性的小分子（NO，NO2，H2S，ClO–等）
高通量筛选方法学的建立
抗衰老药物

荣誉、奖项

高通量筛选方法学的建立汤姆森路透社高被引研究员（2014年和2015年在农业科学中被引用最多的文献的研究人员中排名前1％）。
2018年国立大学化学系杰出化学家奖。

代表性论文

[1] Lu Y, Wang X, Pu H, Lin Y, Li D, Liu SQ, Huang D. 2020. “Moringin and Its Structural Analogues as Slow H2S Donors: Their Mechanisms and Bioactivity”. Journal of Agriculture and Food Chemistry. 68(27):7235-7245.
[2] Zhou F, Guo J, Han X, Gao Y, Chen Q, Huang W, Zhan J, Huang D, You Y. 2020. “Cranberry Polyphenolic Extract Exhibits an Antiobesity Effect on High-Fat Diet-Fed Mice through Increased Thermogenesis”. The Journal of Nutrition. 150(8):2131-2138.
[3] Zhang Y, Yang X, Tang H, Liang D, Wu J, Huang D. 2020. “Pyrenediones as versatile photocatalysts for oxygenation reactions with: In situ generation of hydrogen peroxide under visible light”. Green Chemistry. 22(1):22-27.
[4] Lin Y, Yang X, Lu Y, Liang D, Huang D. 2019. “Isothiocyanates as H2S Donors Triggered by Cysteine: Reaction Mechanism and Structure and Activity Relationship”. Organic Letters. 21(15):5977-5980.
[5] Yang X, Wang T, Guo J, Sun M, Wong MW, Huang D. 2019. “Dietary Flavonoids Scavenge Hypochlorous Acid via Chlorination on A- and C-Rings as Primary Reaction Sites: Structure and Reactivity Relationship”. Journal of Agriculture and Food Chemistry. 67(15):4346-4354.
[6] Sun M, Yang X, Zhang Y, Wang S, Wong MW, Ni R, Huang D. 2019. “Rapid and Visual Detection and Quantitation of Ethylene Released from Ripening Fruits: The New Use of Grubbs Catalyst”. Journal of Agriculture and Food Chemistry. 67(1):507-513.
[7] Liang D, Zhang Y, Wu Z, Chen YJ, Yang X, Sun M, Ni R, Bian J, Huang D. 2018. “A near infrared singlet oxygen probe and its applications in in vivo imaging and measurement of singlet oxygen quenching activity of flavonoids”. Sensors and Actuators B-Chemical. 266:645-654.
[8] Jing L, Wang X, Liu H, Lu Y, Bian J, Sun J, Huang D. 2018. “Zein Increases the Cytoaffinity and Biodegradability of Scaffolds 3D-Printed with Zein and Poly(epsilon-caprolactone) Composite Ink”. ACS Applied Materials & Interfaces. 10(22):18551-18559.
[9] Lehnhardt F, Liang D, Chen Q, Tocmo R, Rychlik M, Huang D. 2017. “Effects of S-allyl glutathione disulphide and vinyl-dithiin isomers from garlic on the chronological lifespan of Saccharomyces cerevisiae”. Journal of Functional Foods. 37:650-657.
[10] Liang D, Bian J, Deng L-W, Huang D. 2017. “Cyclic polysulphide 1,2,4-trithiolane from stinky bean (Parkia speciosa seeds) is a slow releasing hydrogen sulphide (H2S) donor”. Journal of Functional Foods. 35:197-204.
[11] Tocmo R, Liang D, Lin Y, Huang D. 2015. “Chemical and Biochemical Mechanisms Underlying the Cardioprotective Roles of Dietary Organopolysulfides”. Frontiers in Nutrition. 2.
[12] Yan Y, Krishnakumar S, Yu H, Ramishetti S, Deng L-W, Wang S, Huang L, Huang D. 2013. “Nickel(II) Dithiocarbamate Complexes Containing Sulforhodamine B as Fluorescent Probes for Selective Detection of Nitrogen Dioxide”. Journal of the American Chemical Society. 135(14):5312-5315.
[13] Quek Y-L, Tan C-H, Bian J, Huang D. 2011. “Air Oxidation of HS- Catalyzed by An Mixed-Valence Diruthenium Complex, an Near-IR Probe for HS- Detection”. Inorganic Chemistry. 50(16):7379-7381.